Title | Regulation of cardiac myocyte apoptosis by the GATA-4 transcription factor. |
Publication Type | Journal Article |
Year of Publication | 2004 |
Authors | Suzuki YJ, Evans T |
Journal | Life Sci |
Volume | 74 |
Issue | 15 |
Pagination | 1829-38 |
Date Published | 2004 Feb 27 |
ISSN | 0024-3205 |
Keywords | Anthracyclines, Apoptosis, DNA-Binding Proteins, Endothelin-1, GATA4 Transcription Factor, Gene Expression Regulation, Hepatocyte Growth Factor, Humans, Myocytes, Cardiac, Signal Transduction, Transcription Factors |
Abstract | Apoptosis of cardiac muscle cells plays important roles in the development of various heart diseases including myocardial infarction and anthracycline-induced cardiomyopathy. Understanding the regulatory mechanisms of cardiac myocyte apoptosis and survival is important for establishing therapeutic strategies against heart disease. Our recent experiments demonstrate that the GATA-4 transcription factor not only mediates cardiac hypertrophy, but also regulates apoptosis and survival of adult cardiac muscle cells. Apoptosis induced by anthracyclines is associated with decreased expression of GATA-4, while the restoration of GATA-4 levels via ectopic expression attenuated the apoptosis. Survival factors of cardiac myocytes such as hepatocyte growth factor and endothelin-1 activate GATA-4, and this signal transduction mechanism at least in part serves to protect the heart against oxidative stress. |
DOI | 10.1016/j.lfs.2003.10.002 |
Alternate Journal | Life Sci |
PubMed ID | 14761664 |
Grant List | R01 HL56182 / HL / NHLBI NIH HHS / United States R01 HL67940 / HL / NHLBI NIH HHS / United States R01 HL72844 / HL / NHLBI NIH HHS / United States |