Hartman Institute for Therapeutic Organ Regeneration

Regulation of cardiac myocyte apoptosis by the GATA-4 transcription factor.

TitleRegulation of cardiac myocyte apoptosis by the GATA-4 transcription factor.
Publication TypeJournal Article
Year of Publication2004
AuthorsSuzuki YJ, Evans T
JournalLife Sci
Volume74
Issue15
Pagination1829-38
Date Published2004 Feb 27
ISSN0024-3205
KeywordsAnthracyclines, Apoptosis, DNA-Binding Proteins, Endothelin-1, GATA4 Transcription Factor, Gene Expression Regulation, Hepatocyte Growth Factor, Humans, Myocytes, Cardiac, Signal Transduction, Transcription Factors
Abstract

Apoptosis of cardiac muscle cells plays important roles in the development of various heart diseases including myocardial infarction and anthracycline-induced cardiomyopathy. Understanding the regulatory mechanisms of cardiac myocyte apoptosis and survival is important for establishing therapeutic strategies against heart disease. Our recent experiments demonstrate that the GATA-4 transcription factor not only mediates cardiac hypertrophy, but also regulates apoptosis and survival of adult cardiac muscle cells. Apoptosis induced by anthracyclines is associated with decreased expression of GATA-4, while the restoration of GATA-4 levels via ectopic expression attenuated the apoptosis. Survival factors of cardiac myocytes such as hepatocyte growth factor and endothelin-1 activate GATA-4, and this signal transduction mechanism at least in part serves to protect the heart against oxidative stress.

DOI10.1016/j.lfs.2003.10.002
Alternate JournalLife Sci
PubMed ID14761664
Grant ListR01 HL56182 / HL / NHLBI NIH HHS / United States
R01 HL67940 / HL / NHLBI NIH HHS / United States
R01 HL72844 / HL / NHLBI NIH HHS / United States

Weill Cornell Medicine
Hartman Institute for Therapeutic Organ Regeneration
1300 York Ave, Box 136 New York, NY 10065