| Title | Sphingosine 1-phosphate signalling. |
| Publication Type | Journal Article |
| Year of Publication | 2014 |
| Authors | Mendelson K, Evans T, Hla T |
| Journal | Development |
| Volume | 141 |
| Issue | 1 |
| Pagination | 5-9 |
| Date Published | 2014 Jan |
| ISSN | 1477-9129 |
| Keywords | Cell Adhesion, Cell Differentiation, Cell Movement, Cell Survival, Extremities, Heart, Humans, Lysophospholipids, Neovascularization, Physiologic, Neurogenesis, Receptors, Lysosphingolipid, Signal Transduction, Sphingomyelins, Sphingosine |
| Abstract | <p>Sphingosine 1-phosphate (S1P) is a lipid mediator formed by the metabolism of sphingomyelin. In vertebrates, S1P is secreted into the extracellular environment and signals via G protein-coupled S1P receptors to regulate cell-cell and cell-matrix adhesion, and thereby influence cell migration, differentiation and survival. The expression and localization of S1P receptors is dynamically regulated and controls vascular development, vessel stability and immune cell trafficking. In addition, crucial events during embryogenesis, such as angiogenesis, cardiogenesis, limb development and neurogenesis, are regulated by S1P signalling. Here, and in the accompanying poster, we provide an overview of S1P signalling in development and in disease.</p> |
| DOI | 10.1242/dev.094805 |
| Alternate Journal | Development |
| PubMed ID | 24346695 |
| PubMed Central ID | PMC3865745 |
| Grant List | P01 CA077839 / CA / NCI NIH HHS / United States R01 HL111400 / HL / NHLBI NIH HHS / United States R37 HL067330 / HL / NHLBI NIH HHS / United States |