Hartman Institute for Therapeutic Organ Regeneration

Angiocrine functions of organ-specific endothelial cells.

TitleAngiocrine functions of organ-specific endothelial cells.
Publication TypeJournal Article
Year of Publication2016
AuthorsRafii S, Butler JM, Ding B-S
JournalNature
Volume529
Issue7586
Pagination316-25
Date Published2016 Jan 21
ISSN1476-4687
KeywordsAnimals, Capillaries, Cell Differentiation, Cell Self Renewal, Endothelial Cells, Homeostasis, Humans, Liver Cirrhosis, Lung, Neovascularization, Physiologic, Organ Specificity, Osteogenesis, Paracrine Communication, Regeneration
Abstract

<p>Endothelial cells that line capillaries are not just passive conduits for delivering blood. Tissue-specific endothelium establishes specialized vascular niches that deploy sets of growth factors, known as angiocrine factors. These cues participate actively in the induction, specification, patterning and guidance of organ regeneration, as well as in the maintainance of homeostasis and metabolism. When upregulated following injury, they orchestrate self-renewal and differentiation of tissue-specific resident stem and progenitor cells into functional organs. Uncovering the mechanisms by which organotypic endothelium distributes physiological levels of angiocrine factors both spatially and temporally will lay the foundation for clinical trials that promote organ repair without scarring.</p>

DOI10.1038/nature17040
Alternate JournalNature
PubMed ID26791722
PubMed Central IDPMC4878406
Grant ListR01 HL115128 / HL / NHLBI NIH HHS / United States
U54CA163167 / CA / NCI NIH HHS / United States
U54 CA163167 / CA / NCI NIH HHS / United States
R01 HL128158 / HL / NHLBI NIH HHS / United States
R01 DK095039 / DK / NIDDK NIH HHS / United States
R01HL128158 / HL / NHLBI NIH HHS / United States
/ / Howard Hughes Medical Institute / United States
R01HL119872 / HL / NHLBI NIH HHS / United States
R01DK095039 / DK / NIDDK NIH HHS / United States
R01 HL119872 / HL / NHLBI NIH HHS / United States
R01HL115128 / HL / NHLBI NIH HHS / United States

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Hartman Institute for Therapeutic Organ Regeneration
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