| Title | Fishing for a WNT-PGE2 link: beta-catenin is caught in the stem cell net-work. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Evans T |
| Journal | Cell Stem Cell |
| Volume | 4 |
| Issue | 4 |
| Pagination | 280-2 |
| Date Published | 2009 Apr 03 |
| ISSN | 1875-9777 |
| Keywords | Animals, beta Catenin, Cell Differentiation, Cell Line, Tumor, Cell Proliferation, Colonic Neoplasms, Dinoprostone, Models, Animal, Signal Transduction, Stem Cells, Wnt Proteins, Zebrafish, Zebrafish Proteins |
| Abstract | <p>WNT and PGE2 signaling pathways are each associated with stem cell activity in the hematopoietic system. In a recent issue of Cell, Goessling et al. (2009) use the zebrafish model to reveal a conserved PKA-dependent mechanism that connects the two pathways via beta-catenin, enhancing stem cell proliferation and tissue regeneration.</p> |
| DOI | 10.1016/j.stem.2009.03.006 |
| Alternate Journal | Cell Stem Cell |
| PubMed ID | 19341616 |