| Title | The bone marrow vascular niche: home of HSC differentiation and mobilization. |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Kopp H-G, Avecilla ST, Hooper AT, Rafii S |
| Journal | Physiology (Bethesda) |
| Volume | 20 |
| Pagination | 349-56 |
| Date Published | 2005 Oct |
| ISSN | 1548-9213 |
| Keywords | Animals, Blood Vessels, Bone Marrow, Cell Differentiation, Cell Movement, Hematopoietic Stem Cells, Humans, Models, Cardiovascular, Neovascularization, Physiologic |
| Abstract | The bone marrow vascular niche consists of a network of thin-walled and fenestrated sinusoidal vessels whose integrity is maintained and supported by surrounding hematopoietic cells. However, this dependence is highly reciprocal in that the bone marrow vasculature provides not only a conduit for mature hematopoietic cells to the peripheral circulation but also a site where hematopoietic progenitors, especially megakaryocytes, differentiate and set the stage for full reconstitution of hematopoiesis. |
| DOI | 10.1152/physiol.00025.2005 |
| Alternate Journal | Physiology (Bethesda) |
| PubMed ID | 16174874 |