| Title | Vascular frontiers without borders: multifaceted roles of platelet-derived growth factor (PDGF) in supporting postnatal angiogenesis and lymphangiogenesis. |
| Publication Type | Journal Article |
| Year of Publication | 2004 |
| Authors | Vincent L, Rafii S |
| Journal | Cancer Cell |
| Volume | 6 |
| Issue | 4 |
| Pagination | 307-9 |
| Date Published | 2004 Oct |
| ISSN | 1535-6108 |
| Keywords | Animals, Lymphangiogenesis, Neoplasms, Neovascularization, Pathologic, Platelet-Derived Growth Factor, Receptors, Platelet-Derived Growth Factor, Signal Transduction |
| Abstract | The platelet-derived growth factor (PDGF) family of growth factors, which primarily serves the function of stabilizing vascular networks, has now been shown to play a role in promoting tumor lymphangiogenesis. PDGF-BB, independent of VEGFR-3 signaling, induces tumor growth and metastasis in part through supporting lymphangiogenesis. These data suggest that targeting the PDGF/PDGF-receptor signaling pathway will provide a novel strategy to block tumor neoangiogenesis and lymphangiogenesis, thereby inhibiting tumor growth and metastasis. |
| DOI | 10.1016/j.ccr.2004.09.024 |
| Alternate Journal | Cancer Cell |
| PubMed ID | 15488752 |