Title | Vaccination against tumor neovascularization: Promise and reality. |
Publication Type | Journal Article |
Year of Publication | 2002 |
Authors | Rafii S |
Journal | Cancer Cell |
Volume | 2 |
Issue | 6 |
Pagination | 429-31 |
Date Published | 2002 Dec |
ISSN | 1535-6108 |
Keywords | Animals, Cancer Vaccines, Endothelium, Vascular, Genetic Engineering, Humans, Immune Tolerance, Neoplasms, Neovascularization, Pathologic, Vascular Endothelial Growth Factor Receptor-2 |
Abstract | Immunization against angiogenic-associated antigens selectively expressed on tumor vasculature provides for a novel strategy to block tumor growth. The feasibility of this approach has recently been borne out in several reports demonstrating that the protein or DNA of angiogenic molecules, such as VEGF-R2, can be used as vaccines to generate an effective cytotoxic T cell and antibody response against tumor vessels, thereby blocking tumor growth and metastasis. |
DOI | 10.1016/s1535-6108(02)00208-8 |
Alternate Journal | Cancer Cell |
PubMed ID | 12498709 |