| Title | Synthesis of 2-substituted 2H-chromenes using potassium vinyltrifluoroborates. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Liu F, Evans T, Das BC |
| Journal | Tetrahedron Lett |
| Volume | 49 |
| Issue | 10 |
| Pagination | 1578-1581 |
| Date Published | 2008 Mar 03 |
| ISSN | 0040-4039 |
| Abstract | <p>2H-Chromenes were synthesized from salicylaldehyde using potassium vinylic borates in the presence of secondary amines. We synthesized these 2H-chromene derivatives as a part of an ongoing project to develop inhibitors for TGF-β receptors. Potassium vinyl trifluoroborates react with salicylaldehydes at 80 °C in the presence of a secondary amine and produced 2-substituted 2H-chromene derivatives with a 70-90% yield.</p> |
| DOI | 10.1016/j.tetlet.2008.01.008 |
| Alternate Journal | Tetrahedron Lett |
| PubMed ID | 21753857 |
| PubMed Central ID | PMC3132890 |
| Grant List | R37 HL056182 / HL / NHLBI NIH HHS / United States R37 HL056182-14 / HL / NHLBI NIH HHS / United States |