| Title | The regulation of hematopoietic stem cell and progenitor mobilization by chemokine SDF-1. |
| Publication Type | Journal Article |
| Year of Publication | 2003 |
| Authors | Hattori K, Heissig B, Rafii S |
| Journal | Leuk Lymphoma |
| Volume | 44 |
| Issue | 4 |
| Pagination | 575-82 |
| Date Published | 2003 Apr |
| ISSN | 1042-8194 |
| Keywords | Cell Division, Cell Movement, Chemokine CXCL12, Chemokines, Chemokines, CXC, Chemotaxis, Hematopoietic Stem Cells, Humans, Matrix Metalloproteinase 9, Stem Cells, Time Factors |
| Abstract | The chemokine, stromal derived factor-1 (SDF1) has been shown to modulate the homing of stem cells to its site by mediating chemotaxis. We demontrated overexpression of SDF-1 induced mobilization of cells with stem cell potential (CFU-S, long-term reconstituting cells). Moreover, SDF-1 activated matrix metalloproteinase-9 induced in bone marrow (BM) cells, causing the release soluble Kit-ligand and permitting the transfer of hematopoietic stem cells (HSCs) from a quiescent to a proliferative niche. The role of SDF-1 in the process of HSC migration and the mechanism underlying this HSCs migration will be reviewed. These studies lay the foundation for using SDF-1 to induce mobilization of progenitor cells in a BM transplantation setting. |
| DOI | 10.1080/1042819021000037985 |
| Alternate Journal | Leuk Lymphoma |
| PubMed ID | 12769333 |