Hartman Institute for Therapeutic Organ Regeneration
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2023
Xue D, Narisu N, D Taylor L, Zhang M, Grenko C, Taylor HJ, Yan T, Tang X, Sinha N, Zhu J et al..  2023.  Functional interrogation of twenty type 2 diabetes-associated genes using isogenic hESC-derived β-like cells.. bioRxiv.
J Vandana J, Manrique C, Lacko LA, Chen S.  2023.  Human pluripotent-stem-cell-derived organoids for drug discovery and evaluation.. Cell Stem Cell. 30(5):571-591.
Lee D, Le Pen J, Yatim A, Dong B, Aquino Y, Ogishi M, Pescarmona R, Talouarn E, Rinchai D, Zhang P et al..  2023.  Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children.. Science. 379(6632):eabo3627.
Yang L, Han Y, Zhou T, Lacko LA, Saeed M, Tan C, Danziger R, Zhu J, Zhao Z, Cahir C et al..  2023.  Isogenic human trophectoderm cells demonstrate the role of and associated variants in ZIKV infection.. iScience. 26(7):107001.
Elhadad S, Redmond D, Huang J, Tan A, Laurence J.  2023.  MASP2 inhibition by narsoplimab suppresses endotheliopathies characteristic of transplant-associated thrombotic microangiopathy: in vitro and ex vivo evidence.. Clin Exp Immunol. 213(2):252-264.
Savage A, Risquez C, Gomi K, Schreiner R, Borczuk AC, Worgall S, Silver RB.  2023.  The mast cell exosome-fibroblast connection: A novel pro-fibrotic pathway.. Front Med (Lausanne). 10:1139397.
Elosegui-Artola A, Gupta A, Najibi AJ, Seo BRi, Garry R, Tringides CM, de Lázaro I, Darnell M, Gu W, Zhou Q et al..  2023.  Matrix viscoelasticity controls spatiotemporal tissue organization.. Nat Mater. 22(1):117-127.
Hudaiberdiev S, D Taylor L, Song W, Narisu N, Bhuiyan RM, Taylor HJ, Tang X, Yan T, Swift AJ, Bonnycastle LL et al..  2023.  Modeling islet enhancers using deep learning identifies candidate causal variants at loci associated with T2D and glycemic traits.. Proc Natl Acad Sci U S A. 120(35):e2206612120.
Tang X, Xue D, Zhang T, Nilsson-Payant BE, Carrau L, Duan X, Gordillo M, Tan AY, Qiu Y, Xiang J et al..  2023.  A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection.. Nat Cell Biol. 25(3):381-389.
Kubala JM, Laursen KB, Schreiner R, Williams RM, van der Mijn JC, Crowley MJ, Mongan NP, Nanus DM, Heller DA, Gudas LJ.  2023.  NDUFA4L2 reduces mitochondrial respiration resulting in defective lysosomal trafficking in clear cell renal cell carcinoma.. Cancer Biol Ther. 24(1):2170669.
Stamateris RE, Landa-Galvan HV, Sharma RB, Darko C, Redmond D, Rane SG, Alonso LC.  2023.  Noncanonical CDK4 signaling rescues diabetes in a mouse model by promoting β cell differentiation.. J Clin Invest. 133(18)
Sleiman Y, Reiken S, Charrabi A, Jaffré F, Sittenfeld LR, Pasquié J-L, Colombani S, Lerman BB, Chen S, Marks AR et al..  2023.  Personalized medicine in the dish to prevent calcium leak associated with short-coupled polymorphic ventricular tachycardia in patient-derived cardiomyocytes.. Stem Cell Res Ther. 14(1):266.
Moeller TD, Shah SB, Lai K, Lopez-Barbosa N, Desai P, Wang W, Zhong Z, Redmond D, Singh A, DeLisa MP.  2023.  Profiling Germinal Center-like B Cell Responses to Conjugate Vaccines Using Synthetic Immune Organoids.. ACS Cent Sci. 9(4):787-804.
Ramalingam P, Gutkin MC, Poulos MG, Tillery T, Doughty C, Winiarski A, Freire AG, Rafii S, Redmond D, Butler JM.  2023.  Restoring bone marrow niche function rejuvenates aged hematopoietic stem cells by reactivating the DNA Damage Response.. Nat Commun. 14(1):2018.
Luo Y, Yamada M, N'Tumba-Byn T, Asif H, Gao M, Hu Y, Marangoni P, Liu Y, Evans T, Rafii S et al..  2023.  SPRY4-dependent ERK negative feedback demarcates functional adult stem cells in the male mouse germline†.. Biol Reprod. 109(4):533-551.
Hirschhorn D, Budhu S, Kraehenbuehl L, Gigoux M, Schröder D, Chow A, Ricca JM, Gasmi B, De Henau O, Mangarin LMark B et al..  2023.  T cell immunotherapies engage neutrophils to eliminate tumor antigen escape variants.. Cell. 186(7):1432-1447.e17.
Tan L, Duan X, Mutyala P, Zhou T, Amin S, Zhang T, Herbst B, Askan G, Itkin T, Xiang Z et al..  2023.  A targetable pathway to eliminate TRA-1-60+/TRA-1-81+ chemoresistant cancer cells.. J Mol Cell Biol. 15(6)
Hagedorn EJ, Perlin JR, Freeman RJ, Wattrus SJ, Han T, Mao C, Kim JWook, Fernández-Maestre I, Daily ML, D'Amato C et al..  2023.  Transcription factor induction of vascular blood stem cell niches in vivo.. Dev Cell. 58(12):1037-1051.e4.
Itkin T, Houghton S, Schreiner R, Lin Y, Badwe CR, Voisin V, Murison A, Seyedhassantehrani N, Kaufmann KB, Garcia-Prat L et al..  2023.  Transcriptional Activation of Regenerative Hematopoiesis via Vascular Niche Sensing.. bioRxiv.