Hartman Institute for Therapeutic Organ Regeneration

Organoids as tools for fundamental discovery and translation-a Keystone Symposia report.

TitleOrganoids as tools for fundamental discovery and translation-a Keystone Symposia report.
Publication TypeJournal Article
Year of Publication2022
AuthorsCable J, Lutolf MP, Fu J, Park SEstelle, Apostolou A, Chen S, Song CJack, Spence JR, Liberali P, Lancaster M, Meier AB, Pek NMin Qian, Wells JM, Capeling MM, Uzquiano A, Musah S, Huch M, Gouti M, Hombrink P, Quadrato G, Urenda J-P
JournalAnn N Y Acad Sci
Volume1518
Issue1
Pagination196-208
Date Published2022 Dec
ISSN1749-6632
KeywordsAnimals, Humans, Models, Animal, Models, Biological, Organoids, Stem Cells
Abstract

<p>Complex three-dimensional in vitro organ-like models, or organoids, offer a unique biological tool with distinct advantages over two-dimensional cell culture systems, which can be too simplistic, and animal models, which can be too complex and may fail to recapitulate human physiology and pathology. Significant progress has been made in driving stem cells to differentiate into different organoid types, though several challenges remain. For example, many organoid models suffer from high heterogeneity, and it can be difficult to fully incorporate the complexity of in vivo tissue and organ development to faithfully reproduce human biology. Successfully addressing such limitations would increase the viability of organoids as models for drug development and preclinical testing. On April 3-6, 2022, experts in organoid development and biology convened at the Keystone Symposium "Organoids as Tools for Fundamental Discovery and Translation" to discuss recent advances and insights from this relatively new model system into human development and disease.</p>

DOI10.1111/nyas.14874
Alternate JournalAnn N Y Acad Sci
PubMed ID36177906
PubMed Central IDPMC11293861
Grant ListR01 NS129850 / NS / NINDS NIH HHS / United States
R21 NS127983 / NS / NINDS NIH HHS / United States
R01 GM143297 / GM / NIGMS NIH HHS / United States
R21 NS113518 / NH / NIH HHS / United States
R21 NS113518 / NS / NINDS NIH HHS / United States
R21 HD100931 / NH / NIH HHS / United States
R21 HD105126 / HD / NICHD NIH HHS / United States
R21 HD109635 / HD / NICHD NIH HHS / United States
R21 HD100931 / HD / NICHD NIH HHS / United States
R21 HD105192 / HD / NICHD NIH HHS / United States
T32 HD060549 / HD / NICHD NIH HHS / United States
MC_UP_1201/9 / MRC_ / Medical Research Council / United Kingdom

Weill Cornell Medicine
Hartman Institute for Therapeutic Organ Regeneration
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