Hartman Institute for Therapeutic Organ Regeneration

Preparing the "soil": the premetastatic niche.

TitlePreparing the "soil": the premetastatic niche.
Publication TypeJournal Article
Year of Publication2006
AuthorsKaplan RN, Rafii S, Lyden D
JournalCancer Res
Volume66
Issue23
Pagination11089-93
Date Published2006 Dec 01
ISSN0008-5472
KeywordsBone Marrow Cells, Cell Adhesion, Chemokines, Fibronectins, Humans, Matrix Metalloproteinases, Models, Biological, Neoplasm Metastasis, Neoplasms, Vascular Endothelial Growth Factor Receptor-1
Abstract

Current focus on cancer metastasis has centered on the intrinsic factors regulating the cell autonomous homing of the tumor cells to the metastatic site. Specific up-regulation of fibronectin and clustering of bone marrow-derived cellular infiltrates coexpressing matrix metalloproteinases in distant tissue sites before tumor cell arrival are proving to be indispensable for the initial stages of metastasis. These bone marrow-derived hematopoietic progenitors that express vascular endothelial growth factor receptor 1 mobilize in response to the unique array of growth factors produced by the primary tumor. Their arrival in distant sites represents early changes in the local microenvironment, termed the "premetastatic niche," which dictate the pattern of metastatic spread. Focus on the early cellular and molecular events in cancer dissemination and selectivity will likely lead to new approaches to detect and prevent metastasis at its earliest inception.

DOI10.1158/0008-5472.CAN-06-2407
Alternate JournalCancer Res
PubMed ID17145848
PubMed Central IDPMC2952469
Grant ListP01 HL067839-020004 / HL / NHLBI NIH HHS / United States
R01 HL058707-04 / HL / NHLBI NIH HHS / United States
P01 HL067839 / HL / NHLBI NIH HHS / United States
R01 CA098234 / CA / NCI NIH HHS / United States
R01 HL058707-03 / HL / NHLBI NIH HHS / United States
R01 HL061849-03S1 / HL / NHLBI NIH HHS / United States
R01 HL061849-05 / HL / NHLBI NIH HHS / United States
P01 HL067839-010004 / HL / NHLBI NIH HHS / United States
R01 HL061849-02 / HL / NHLBI NIH HHS / United States
/ HHMI / Howard Hughes Medical Institute / United States
P01 HL067839-040004 / HL / NHLBI NIH HHS / United States
R01 HL061849-04 / HL / NHLBI NIH HHS / United States
R01CA098234 / CA / NCI NIH HHS / United States
R01 HL061849-03 / HL / NHLBI NIH HHS / United States
R01 HL061849 / HL / NHLBI NIH HHS / United States
P01 HL067839-050004 / HL / NHLBI NIH HHS / United States
P01 HL067839-030004 / HL / NHLBI NIH HHS / United States

Weill Cornell Medicine
Hartman Institute for Therapeutic Organ Regeneration
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