Title | Preparing the "soil": the premetastatic niche. |
Publication Type | Journal Article |
Year of Publication | 2006 |
Authors | Kaplan RN, Rafii S, Lyden D |
Journal | Cancer Res |
Volume | 66 |
Issue | 23 |
Pagination | 11089-93 |
Date Published | 2006 Dec 01 |
ISSN | 0008-5472 |
Keywords | Bone Marrow Cells, Cell Adhesion, Chemokines, Fibronectins, Humans, Matrix Metalloproteinases, Models, Biological, Neoplasm Metastasis, Neoplasms, Vascular Endothelial Growth Factor Receptor-1 |
Abstract | Current focus on cancer metastasis has centered on the intrinsic factors regulating the cell autonomous homing of the tumor cells to the metastatic site. Specific up-regulation of fibronectin and clustering of bone marrow-derived cellular infiltrates coexpressing matrix metalloproteinases in distant tissue sites before tumor cell arrival are proving to be indispensable for the initial stages of metastasis. These bone marrow-derived hematopoietic progenitors that express vascular endothelial growth factor receptor 1 mobilize in response to the unique array of growth factors produced by the primary tumor. Their arrival in distant sites represents early changes in the local microenvironment, termed the "premetastatic niche," which dictate the pattern of metastatic spread. Focus on the early cellular and molecular events in cancer dissemination and selectivity will likely lead to new approaches to detect and prevent metastasis at its earliest inception. |
DOI | 10.1158/0008-5472.CAN-06-2407 |
Alternate Journal | Cancer Res |
PubMed ID | 17145848 |
PubMed Central ID | PMC2952469 |
Grant List | P01 HL067839-020004 / HL / NHLBI NIH HHS / United States R01 HL058707-04 / HL / NHLBI NIH HHS / United States P01 HL067839 / HL / NHLBI NIH HHS / United States R01 CA098234 / CA / NCI NIH HHS / United States R01 HL058707-03 / HL / NHLBI NIH HHS / United States R01 HL061849-03S1 / HL / NHLBI NIH HHS / United States R01 HL061849-05 / HL / NHLBI NIH HHS / United States P01 HL067839-010004 / HL / NHLBI NIH HHS / United States R01 HL061849-02 / HL / NHLBI NIH HHS / United States / HHMI / Howard Hughes Medical Institute / United States P01 HL067839-040004 / HL / NHLBI NIH HHS / United States R01 HL061849-04 / HL / NHLBI NIH HHS / United States R01CA098234 / CA / NCI NIH HHS / United States R01 HL061849-03 / HL / NHLBI NIH HHS / United States R01 HL061849 / HL / NHLBI NIH HHS / United States P01 HL067839-050004 / HL / NHLBI NIH HHS / United States P01 HL067839-030004 / HL / NHLBI NIH HHS / United States |