Hartman Institute for Therapeutic Organ Regeneration

Maladapted endothelial cells flip the mesenchymal switch.

TitleMaladapted endothelial cells flip the mesenchymal switch.
Publication TypeJournal Article
Year of Publication2014
AuthorsJames D, Rafii S
JournalSci Transl Med
Volume6
Issue227
Pagination227fs12
Date Published2014 Mar 12
ISSN1946-6242
KeywordsAnimals, Cell Transdifferentiation, Endothelial Cells, Humans, Mesoderm, Signal Transduction, Transforming Growth Factor beta, Veins
Abstract

<p>Endothelial cells in the neointima undergo a transition to the mesenchymal phenotype, suggesting a therapeutic target for vein graft restenosis (Cooley et al., this issue).</p>

DOI10.1126/scitranslmed.3008623
Alternate JournalSci Transl Med
PubMed ID24622512

Weill Cornell Medicine
Hartman Institute for Therapeutic Organ Regeneration
1300 York Ave, Box 136 New York, NY 10065