| Title | Leukemic Cells "Gas Up" Leaky Bone Marrow Blood Vessels. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Itkin T, Rafii S |
| Journal | Cancer Cell |
| Volume | 32 |
| Issue | 3 |
| Pagination | 276-278 |
| Date Published | 2017 Sep 11 |
| ISSN | 1878-3686 |
| Keywords | Bone Marrow, Bone Marrow Cells, Hematopoietic Stem Cells, Humans, Leukemia, Nitric Oxide, Stem Cells |
| Abstract | <p>In this issue of Cancer Cell, Passaro et al. demonstrate how leukemia through aberrant induction of reactive oxygen species and nitric oxide production trigger marrow vessel leakiness, instigating pro-leukemic function. Disrupted tumor blood vessels promote exhaustion of non-malignant stem and progenitor cells and may facilitate leukemia relapse following chemotherapeutic treatment.</p> |
| DOI | 10.1016/j.ccell.2017.08.012 |
| Alternate Journal | Cancer Cell |
| PubMed ID | 28898691 |