Title | Leukemic Cells "Gas Up" Leaky Bone Marrow Blood Vessels. |
Publication Type | Journal Article |
Year of Publication | 2017 |
Authors | Itkin T, Rafii S |
Journal | Cancer Cell |
Volume | 32 |
Issue | 3 |
Pagination | 276-278 |
Date Published | 2017 Sep 11 |
ISSN | 1878-3686 |
Keywords | Bone Marrow, Bone Marrow Cells, Hematopoietic Stem Cells, Humans, Leukemia, Nitric Oxide, Stem Cells |
Abstract | <p>In this issue of Cancer Cell, Passaro et al. demonstrate how leukemia through aberrant induction of reactive oxygen species and nitric oxide production trigger marrow vessel leakiness, instigating pro-leukemic function. Disrupted tumor blood vessels promote exhaustion of non-malignant stem and progenitor cells and may facilitate leukemia relapse following chemotherapeutic treatment.</p> |
DOI | 10.1016/j.ccell.2017.08.012 |
Alternate Journal | Cancer Cell |
PubMed ID | 28898691 |