Title | New dimensions in vascular engineering: opportunities for cancer biology. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Rabbany SY, James D, Rafii S |
Journal | Tissue Eng Part A |
Volume | 16 |
Issue | 7 |
Pagination | 2157-9 |
Date Published | 2010 Jul |
ISSN | 1937-335X |
Keywords | Animals, Cell Culture Techniques, Cell Transformation, Neoplastic, Humans, Neoplasms, Neovascularization, Pathologic, Neovascularization, Physiologic, Regenerative Medicine, Tissue Engineering, Tissue Scaffolds |
Abstract | <p>Angiogenesis is a fundamental prerequisite for tissue growth and thus an attractive target for cancer therapeutics. However, current efforts to halt tumor growth using antiangiogenic agents have been met with limited success. A reason for this may be that studies aimed at understanding tissue and organ formation have to this point utilized two-dimensional cell culture techniques, which fail to faithfully mimic the pathological architecture of disease in an in vivo context. In this issue of Tissue Engineering, the work of Fischbach-Teschl's group manipulate such variables as oxygen concentration, culture three-dimensionality, and cell-extracellular matrix interactions to more closely approximate the biophysical and biochemical microenvironment of tumor angiogenesis. In this article, we discuss how novel tissue engineering platforms provide a framework for the study of tumorigenesis under pathophysiologically relevant in vitro culture conditions.</p> |
DOI | 10.1089/ten.TEA.2010.0183 |
Alternate Journal | Tissue Eng Part A |
PubMed ID | 20367255 |
PubMed Central ID | PMC2947931 |
Grant List | R01HL075234 / HL / NHLBI NIH HHS / United States U01 HL066952 / HL / NHLBI NIH HHS / United States R01 HL058707 / HL / NHLBI NIH HHS / United States P50 HL084936 / HL / NHLBI NIH HHS / United States R01HL097797 / HL / NHLBI NIH HHS / United States RC1 AI080309 / AI / NIAID NIH HHS / United States R01 HL097797 / HL / NHLBI NIH HHS / United States R01 HL075234 / HL / NHLBI NIH HHS / United States R21 HL083222 / HL / NHLBI NIH HHS / United States / HHMI / Howard Hughes Medical Institute / United States P01 HL067839 / HL / NHLBI NIH HHS / United States P01 HL059312 / HL / NHLBI NIH HHS / United States R01 HL061849 / HL / NHLBI NIH HHS / United States |