Hartman Institute for Therapeutic Organ Regeneration

Interleukin-5 and the regulation of eosinophil production.

TitleInterleukin-5 and the regulation of eosinophil production.
Publication TypeJournal Article
Year of Publication1999
AuthorsRoboz GJ, Rafii S
JournalCurr Opin Hematol
Volume6
Issue3
Pagination164-8
Date Published1999 May
ISSN1065-6251
KeywordsAnimals, Eosinophils, Hematopoiesis, Humans, Interleukin-5, Rhinitis, Allergic, Perennial, Rhinitis, Allergic, Seasonal
Abstract

Eosinophils play important roles in adaptive immune responses, inflammatory processes, and disease states. Recently, considerable research has been devoted to better defining the normal and abnormal biology of these cells, specifically their origin and mechanisms of stimulation, chemotaxis, regulation, and activation. Interleukin-5 has been identified as a major regulator of eosinophil development and function. This review highlights current literature on interleukin-5 and eosinophil production. Areas covered include molecular signaling, physiologic sources of interleukin-5, and interactions between interleukin-5, eosinophils, and the bone marrow microenvironment. Clinical correlates are also presented.

DOI10.1097/00062752-199905000-00007
Alternate JournalCurr Opin Hematol
PubMed ID10226737
Grant ListR01-HL-58707-02 / HL / NHLBI NIH HHS / United States
R01-HL-61849-01 / HL / NHLBI NIH HHS / United States

Weill Cornell Medicine
Hartman Institute for Therapeutic Organ Regeneration
1300 York Ave, Box 136 New York, NY 10065