Title | Instructive role of the vascular niche in promoting tumour growth and tissue repair by angiocrine factors. |
Publication Type | Journal Article |
Year of Publication | 2010 |
Authors | Butler JM, Kobayashi H, Rafii S |
Journal | Nat Rev Cancer |
Volume | 10 |
Issue | 2 |
Pagination | 138-46 |
Date Published | 2010 Feb |
ISSN | 1474-1768 |
Keywords | Angiogenesis Inhibitors, Animals, Disease Progression, Endothelium, Vascular, Growth Substances, Humans, Neoplasms, Neoplastic Stem Cells, Neovascularization, Pathologic |
Abstract | <p>The precise mechanisms whereby anti-angiogenesis therapy blocks tumour growth or causes vascular toxicity are unknown. We propose that endothelial cells establish a vascular niche that promotes tumour growth and tissue repair not only by delivering nutrients and O2 but also through an 'angiocrine' mechanism by producing stem and progenitor cell-active trophogens. Identification of endothelial-derived instructive angiocrine factors will allow direct tumour targeting, while diminishing the unwanted side effects associated with the use of anti-angiogenic agents.</p> |
DOI | 10.1038/nrc2791 |
Alternate Journal | Nat Rev Cancer |
PubMed ID | 20094048 |
PubMed Central ID | PMC2944775 |
Grant List | U01 HL066952 / HL / NHLBI NIH HHS / United States R01 HL058707 / HL / NHLBI NIH HHS / United States P50 HL084936 / HL / NHLBI NIH HHS / United States P01 HL072942 / HL / NHLBI NIH HHS / United States P01 HL067839 / HL / NHLBI NIH HHS / United States R01 HL075234 / HL / NHLBI NIH HHS / United States R21 HL083222 / HL / NHLBI NIH HHS / United States R01 HL097797 / HL / NHLBI NIH HHS / United States / HHMI / Howard Hughes Medical Institute / United States P01 HL059312 / HL / NHLBI NIH HHS / United States R01 HL061849 / HL / NHLBI NIH HHS / United States |