| Title | Identification of a novel family of oligodendrocyte lineage-specific basic helix-loop-helix transcription factors. |
| Publication Type | Journal Article |
| Year of Publication | 2000 |
| Authors | Zhou Q, Wang S, Anderson DJ |
| Journal | Neuron |
| Volume | 25 |
| Issue | 2 |
| Pagination | 331-43 |
| Date Published | 2000 Feb |
| ISSN | 0896-6273 |
| Keywords | Animals, Basic Helix-Loop-Helix Transcription Factors, Cell Lineage, Chick Embryo, DNA-Binding Proteins, Gene Expression Regulation, Developmental, Gene Library, Genetic Testing, Helix-Loop-Helix Motifs, High Mobility Group Proteins, Mesencephalon, Mice, Molecular Sequence Data, Multigene Family, Nerve Tissue Proteins, Oligodendrocyte Transcription Factor 2, Oligodendroglia, Rhombencephalon, Sequence Homology, Amino Acid, SOXE Transcription Factors, Spinal Cord, Stem Cells, Transcription Factors |
| Abstract | Basic helix-loop-helix (bHLH) transcription factors have been identified for neurons and their precursors but not for glial cells. We have identified two bHLH factors, Oligo1 and Oligo2, that are specifically expressed in zones of neuroepithelium from which oligodendrocyte precursors emerge, as well as in the precursors themselves. Expression of Oligo2 in the spinal cord precedes that of platelet-derived growth factor receptor alpha (PDGFRalpha), the earliest known marker of oligodendrocyte precursors, by several days. Ectopic expression of Oligo2 in vivo causes ectopic expression of Sox10, an HMG-box transcription factor expressed in oligodendrocyte and other glial precursors. These data identify Oligo genes as the earliest known markers of oligodendrocyte lineage determination and suggest they play a causal role in this process. |
| DOI | 10.1016/s0896-6273(00)80898-3 |
| Alternate Journal | Neuron |
| PubMed ID | 10719889 |
| Grant List | R01 NS23476 / NS / NINDS NIH HHS / United States |