| Title | Extreme makeover: converting one cell into another. |
| Publication Type | Journal Article |
| Year of Publication | 2008 |
| Authors | Zhou Q, Melton DA |
| Journal | Cell Stem Cell |
| Volume | 3 |
| Issue | 4 |
| Pagination | 382-8 |
| Date Published | 2008 Oct 09 |
| ISSN | 1875-9777 |
| Keywords | Cell Lineage, Cell Transdifferentiation, Cellular Reprogramming, Epigenesis, Genetic, Humans, Insulin-Secreting Cells, Pancreas, Exocrine, Pluripotent Stem Cells, Regeneration, Regenerative Medicine, Stem Cell Niche |
| Abstract | Cells of adult mammals can be converted (reprogrammed) to new cells. In one approach, adult cells are converted to pluripotent stem cells, followed by differentiation to regenerate new cell types. Alternatively, adult cells may be directly converted into other mature cells or progenitors. We discuss and compare these two approaches with particular emphasis on the latter and its relevance for regenerative medicine. |
| DOI | 10.1016/j.stem.2008.09.015 |
| Alternate Journal | Cell Stem Cell |
| PubMed ID | 18940730 |
| Grant List | / / Howard Hughes Medical Institute / United States |