Hartman Institute for Therapeutic Organ Regeneration

Epigenetic Regulation of Cardiac Development and Disease through DNA Methylation.

TitleEpigenetic Regulation of Cardiac Development and Disease through DNA Methylation.
Publication TypeJournal Article
Year of Publication2019
AuthorsLan Y, Evans T
JournalJ Life Sci (Westlake Village)
Volume1
Issue2
Pagination1-10
Date Published2019 Sep
ISSN2688-1020
Abstract

<p>Epigenetic control mechanisms play critical roles in organ development and tissue homeostasis. Increasing evidence suggests that cardiac lineage commitment and cardiovascular disease are tightly regulated by epigenetic mechanisms, controlling changes in DNA methylation, histone modifications, ATP-dependent chromatin remodeling, and expression levels for non-coding RNAs. This review summarizes our current understanding of epigenetic control mechanisms regulating cardiac development and disease, particularly focuses on the function of DNA methylation and demethylation through families of DNA methyltransferases and dioxygenases.</p>

DOI10.1161/CIRCRESAHA.110.227405
Alternate JournalJ Life Sci (Westlake Village)
PubMed ID31595268
PubMed Central IDPMC6783123
Grant ListR35 HL135778 / HL / NHLBI NIH HHS / United States

Weill Cornell Medicine
Hartman Institute for Therapeutic Organ Regeneration
1300 York Ave, Box 136 New York, NY 10065