Hartman Institute for Therapeutic Organ Regeneration

Does N-cadherin regulate interaction of hematopoietic stem cells with their niches?

TitleDoes N-cadherin regulate interaction of hematopoietic stem cells with their niches?
Publication TypeJournal Article
Year of Publication2007
AuthorsHooper AT, Butler J, Petit I, Rafii S
JournalCell Stem Cell
Volume1
Issue2
Pagination127-9
Date Published2007 Aug 16
ISSN1875-9777
KeywordsAnimals, Cadherins, Cell Adhesion, Hematopoietic Stem Cells, Mice, Osteoblasts
Abstract

<p>In this issue of Cell Stem Cell, Kiel et al. (2007) demonstrate that N-cadherin is not expressed on repopulating hematopoietic stem cells (HSCs) and that reduction of osteoblasts does not affect HSC frequency, suggesting that other molecular pathways may also modulate the interaction of HSCs with their niches.</p>

DOI10.1016/j.stem.2007.07.012
Alternate JournalCell Stem Cell
PubMed ID18371341
PubMed Central IDPMC2951616
Grant ListP01 HL059312-090006 / HL / NHLBI NIH HHS / United States
P50 HL084936 / HL / NHLBI NIH HHS / United States
P01 HL059312-100006 / HL / NHLBI NIH HHS / United States
P50 HL084936-010003 / HL / NHLBI NIH HHS / United States
P01 HL059312 / HL / NHLBI NIH HHS / United States
P01 HL059312-080006 / HL / NHLBI NIH HHS / United States
/ HHMI / Howard Hughes Medical Institute / United States
R21 HL083222-01 / HL / NHLBI NIH HHS / United States
P01 HL067839-020004 / HL / NHLBI NIH HHS / United States
R21 HL083222-02 / HL / NHLBI NIH HHS / United States
P01 HL067839 / HL / NHLBI NIH HHS / United States
P50 HL084936-030003 / HL / NHLBI NIH HHS / United States
P01 HL059312-060006 / HL / NHLBI NIH HHS / United States
P50 HL084936-020003 / HL / NHLBI NIH HHS / United States
P01 HL067839-050004 / HL / NHLBI NIH HHS / United States
P01 HL067839-030004 / HL / NHLBI NIH HHS / United States
P01 HL059312-070006 / HL / NHLBI NIH HHS / United States
P50 HL084936-040003 / HL / NHLBI NIH HHS / United States
P01 HL067839-010004 / HL / NHLBI NIH HHS / United States
P01 HL067839-040004 / HL / NHLBI NIH HHS / United States
R21 HL083222 / HL / NHLBI NIH HHS / United States

Weill Cornell Medicine
Hartman Institute for Therapeutic Organ Regeneration
1300 York Ave, Box 136 New York, NY 10065