| Title | Design and Synthesis of Potential New Apoptosis Agents: Hybrid Compounds Containing Perillyl Alcohol and New Constrained Retinoids. |
| Publication Type | Journal Article |
| Year of Publication | 2010 |
| Authors | Das BC, Mahalingam SM, Panda L, Wang B, Campbell P, Evans T |
| Journal | Tetrahedron Lett |
| Volume | 51 |
| Issue | 11 |
| Pagination | 1462-1466 |
| Date Published | 2010 Mar 17 |
| ISSN | 0040-4039 |
| Abstract | <p>Novel retinoids 1-3 containing perillyl alcohol were synthesized through the addition of perillyl alcohol to the activated carboxylic acids (retinoids) promoted by DCC (N, N'-Dicylohexyl cabodiimide). A set of structurally and functionally diverse perillyl alcohol derivatives of retinoids were obtained in good yields (78-82%). Biological evaluation of these novel hybrid compounds (containing retinoids and perillyl alcohol) is currently underway in our laboratory.</p> |
| DOI | 10.1016/j.tetlet.2010.01.003 |
| Alternate Journal | Tetrahedron Lett |
| PubMed ID | 20379349 |
| PubMed Central ID | PMC2849109 |
| Grant List | R01 HL064282-10 / HL / NHLBI NIH HHS / United States R01 HL064282 / HL / NHLBI NIH HHS / United States R37 HL056182-13 / HL / NHLBI NIH HHS / United States R01 HL056182 / HL / NHLBI NIH HHS / United States R37 HL056182 / HL / NHLBI NIH HHS / United States |