| Title | Design and synthesis of (E)-1-((3-ethyl-2,4,4-trimethylcyclohex-2-enylidene)methyl-4-substituted benzenes from 1-(2,6,6-trimethylcyclohex-1-enyl)ethanol. |
| Publication Type | Journal Article |
| Year of Publication | 2009 |
| Authors | Das BC, Mahalingam SM, Evans T, Kabalka GW, Anguiano J, Hema K |
| Journal | Chem Commun (Camb) |
| Issue | 16 |
| Pagination | 2133-5 |
| Date Published | 2009 Apr 28 |
| ISSN | 1359-7345 |
| Keywords | Benzene Derivatives, Cyclohexenes, Magnetic Resonance Spectroscopy, Mass Spectrometry |
| Abstract | <p>A novel strategy for synthesizing (E)-1-((3-ethyl-2,4,4-trimethylcyclohex-2-enylidene)methyl-4-substituted benzenes from 1-(2,6,6-trimethylcyclohex-1-enyl)ethanol has been developed; the allylic alcohol was treated with PPh(3).HBr in methanol followed by aldehydes in the presence of a base and furnished the 1,3-dienes in moderate to good yields (79-86%).</p> |
| DOI | 10.1039/b823063c |
| Alternate Journal | Chem Commun (Camb) |
| PubMed ID | 19360170 |
| PubMed Central ID | PMC3140768 |
| Grant List | R37 HL056182 / HL / NHLBI NIH HHS / United States R37 HL056182-14 / HL / NHLBI NIH HHS / United States |