| Title | Dangerous Liaisons: Deviant Endothelium NOTCHes toward Tumor Metastasis. |
| Publication Type | Journal Article |
| Year of Publication | 2017 |
| Authors | Guo P, Rafii S |
| Journal | Cancer Cell |
| Volume | 31 |
| Issue | 3 |
| Pagination | 301-303 |
| Date Published | 2017 Mar 13 |
| ISSN | 1878-3686 |
| Keywords | Cell Adhesion, Cell Line, Tumor, Endothelial Cells, Endothelium, Endothelium, Vascular, Humans, Signal Transduction |
| Abstract | <p>In this issue of Cancer Cell, Wieland et al. uncover a feedback loop in which tumor cells, by augmenting Notch signaling, provoke a senescent and pro-inflammatory state in endothelial cells, promoting neutrophil infiltration, tumor cell adhesion, and metastasis. Interfering with this Notch-dependent crosstalk may be a therapeutic approach to block metastasis.</p> |
| DOI | 10.1016/j.ccell.2017.02.016 |
| Alternate Journal | Cancer Cell |
| PubMed ID | 28292430 |