Hartman Institute for Therapeutic Organ Regeneration

Angiocrine endothelium: from physiology to cancer.

TitleAngiocrine endothelium: from physiology to cancer.
Publication TypeJournal Article
Year of Publication2020
AuthorsPasquier J, Ghiabi P, Chouchane L, Razzouk K, Rafii S, Rafii A
JournalJ Transl Med
Volume18
Issue1
Pagination52
Date Published2020 Feb 03
ISSN1479-5876
KeywordsEndothelial Cells, Endothelium, Humans, Neoplasms, Neovascularization, Pathologic, Tumor Microenvironment
Abstract

<p>The concept of cancer as a cell-autonomous disease has been challenged by the wealth of knowledge gathered in the past decades on the importance of tumor microenvironment (TM) in cancer progression and metastasis. The significance of endothelial cells (ECs) in this scenario was initially attributed to their role in vasculogenesis and angiogenesis that is critical for tumor initiation and growth. Nevertheless, the identification of endothelial-derived angiocrine factors illustrated an alternative non-angiogenic function of ECs contributing to both physiological and pathological tissue development. Gene expression profiling studies have demonstrated distinctive expression patterns in tumor-associated endothelial cells that imply a bilateral crosstalk between tumor and its endothelium. Recently, some of the molecular determinants of this reciprocal interaction have been identified which are considered as potential targets for developing novel anti-angiocrine therapeutic strategies.</p>

DOI10.1186/s12967-020-02244-9
Alternate JournalJ Transl Med
PubMed ID32014047
PubMed Central IDPMC6998193

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Hartman Institute for Therapeutic Organ Regeneration
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