| Title | AC133/CD133/Prominin-1. |
| Publication Type | Journal Article |
| Year of Publication | 2005 |
| Authors | Shmelkov SV, St Clair R, Lyden D, Rafii S |
| Journal | Int J Biochem Cell Biol |
| Volume | 37 |
| Issue | 4 |
| Pagination | 715-9 |
| Date Published | 2005 Apr |
| ISSN | 1357-2725 |
| Keywords | AC133 Antigen, Alternative Splicing, Antigens, CD, Glycoproteins, Hydrolysis, Peptides, RNA, Messenger |
| Abstract | Prominin-1, originally found on neuroepithelial stem cells in mice, is a five transmembrane domain cell-surface glycoprotein that localizes to membrane protrusions. Its homologue human Prominin-1 was first isolated from hematopoietic stem cells by a monoclonal antibody recognizing a specific epitope designated as AC133 (CD133). Transcription of Prominin-1 is driven by five tissue-specific alternative promoters resulting in the formation of differentially spliced mRNA isoforms. Prominin-1 is expressed on different types of stem cells, but it is not known if it plays a significant role in key stem cell functional features. Although the biological function of Prominin-1 is not well understood, the AC133 epitope currently serves as a useful marker for the isolation of hematopoietic and endothelial progenitor cells. |
| DOI | 10.1016/j.biocel.2004.08.010 |
| Alternate Journal | Int J Biochem Cell Biol |
| PubMed ID | 15694831 |