Title | AC133/CD133/Prominin-1. |
Publication Type | Journal Article |
Year of Publication | 2005 |
Authors | Shmelkov SV, St Clair R, Lyden D, Rafii S |
Journal | Int J Biochem Cell Biol |
Volume | 37 |
Issue | 4 |
Pagination | 715-9 |
Date Published | 2005 Apr |
ISSN | 1357-2725 |
Keywords | AC133 Antigen, Alternative Splicing, Antigens, CD, Glycoproteins, Hydrolysis, Peptides, RNA, Messenger |
Abstract | Prominin-1, originally found on neuroepithelial stem cells in mice, is a five transmembrane domain cell-surface glycoprotein that localizes to membrane protrusions. Its homologue human Prominin-1 was first isolated from hematopoietic stem cells by a monoclonal antibody recognizing a specific epitope designated as AC133 (CD133). Transcription of Prominin-1 is driven by five tissue-specific alternative promoters resulting in the formation of differentially spliced mRNA isoforms. Prominin-1 is expressed on different types of stem cells, but it is not known if it plays a significant role in key stem cell functional features. Although the biological function of Prominin-1 is not well understood, the AC133 epitope currently serves as a useful marker for the isolation of hematopoietic and endothelial progenitor cells. |
DOI | 10.1016/j.biocel.2004.08.010 |
Alternate Journal | Int J Biochem Cell Biol |
PubMed ID | 15694831 |