Hartman Institute for Therapeutic Organ Regeneration

AC133/CD133/Prominin-1.

TitleAC133/CD133/Prominin-1.
Publication TypeJournal Article
Year of Publication2005
AuthorsShmelkov SV, St Clair R, Lyden D, Rafii S
JournalInt J Biochem Cell Biol
Volume37
Issue4
Pagination715-9
Date Published2005 Apr
ISSN1357-2725
KeywordsAC133 Antigen, Alternative Splicing, Antigens, CD, Glycoproteins, Hydrolysis, Peptides, RNA, Messenger
Abstract

Prominin-1, originally found on neuroepithelial stem cells in mice, is a five transmembrane domain cell-surface glycoprotein that localizes to membrane protrusions. Its homologue human Prominin-1 was first isolated from hematopoietic stem cells by a monoclonal antibody recognizing a specific epitope designated as AC133 (CD133). Transcription of Prominin-1 is driven by five tissue-specific alternative promoters resulting in the formation of differentially spliced mRNA isoforms. Prominin-1 is expressed on different types of stem cells, but it is not known if it plays a significant role in key stem cell functional features. Although the biological function of Prominin-1 is not well understood, the AC133 epitope currently serves as a useful marker for the isolation of hematopoietic and endothelial progenitor cells.

DOI10.1016/j.biocel.2004.08.010
Alternate JournalInt J Biochem Cell Biol
PubMed ID15694831

Weill Cornell Medicine
Hartman Institute for Therapeutic Organ Regeneration
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