Hartman Institute for Therapeutic Organ Regeneration
Rafii Shahin

Shahin Rafii, M.D.
Director

A Message From the Director

“We are witnessing the birth of a new field of cellular therapeutics to build replacement ‘mini-organs’ that have tremendous potential for curing disease relieving human suffering.”

Every year millions of patients worldwide succumb to organ failure, who could have otherwise been cured with tissue replacement therapies. While organ transplantation has been available for many decades, it will never be the solution we had hoped for due to a lack of donor-derived organ availability. Furthermore, the cost of managing patients with organ damage, including cardiovascular, lung, liver, kidney, diabetes, Alzheimer’s, Parkinson’s, and post-COVID-19 maladies is in trillions of dollars. Therefore, there is an urgent need to develop effective therapies to mitigate the plight of patients suffering from terminal organ diseases.

Under the stewardship of Dr. Augustine Choi, Weill Cornell Medicine is well-positioned to expand the frontiers of regenerative medicine and pharmaceuticals to the clinic, by establishing the Hartman Institute for Therapeutic Organ Regeneration. This initiative is timely and will lead to discoveries for the treatment of disorders that afflict millions of people worldwide. The recent pandemic was a wake-up call underscoring the revelation that valid scientific evidence and breakthroughs could save humanity and improve the well-being of everyone of different nationalities and ethnic backgrounds.

Thanks to the pioneers at Weill Cornell Medicine (WCM), scientists have already devised patented breakthroughs and innovated game-changing technologies to fully realize the promise of tissue-specific organoids for repairing injured and malfunctioning organs

FLIpping the Switch: Boosting Stem Cell Numbers for Therapies

A single molecular switch is essential for blood stem cells to enter an activated, regenerative state in which they produce new blood cells, according to a preclinical study led by Weill Cornell Medicine investigators. The discovery could lead to more effective bone marrow transplants and gene therapies.

Islet Transplantation with Blood Vessel Cells Shows Promise to Treat Type 1 Diabetes

Adding engineered human blood vessel-forming cells to islet transplants boosted the survival of the insulin-producing cells and reversed diabetes in a preclinical study led by Weill Cornell Medicine investigators. The new approach, which requires further development and testing, could someday enable the much wider use of islet transplants to cure diabetes.

Mapping of Specialized Blood Vessel Cells May Lead to Diabetes Treatments

The distinct population of endothelial cells that line blood vessels in the insulin-producing “islets” of the human pancreas have been notoriously difficult to study, but Weill Cornell Medicine investigators have now succeeded in comprehensively detailing the unique characteristics of these cells.

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