Hartman Institute for Therapeutic Organ Regeneration
Rafii Shahin

Shahin Rafii, M.D.
Director

A Message From the Director

“We are witnessing the birth of a new field of cellular therapeutics to build replacement ‘mini-organs’ that have tremendous potential for curing disease relieving human suffering.”

Every year millions of patients worldwide succumb to organ failure, who could have otherwise been cured with tissue replacement therapies. While organ transplantation has been available for many decades, it will never be the solution we had hoped for due to a lack of donor-derived organ availability. Furthermore, the cost of managing patients with organ damage, including cardiovascular, lung, liver, kidney, diabetes, Alzheimer’s, Parkinson’s, and post-COVID-19 maladies is in trillions of dollars. Therefore, there is an urgent need to develop effective therapies to mitigate the plight of patients suffering from terminal organ diseases.

Under the stewardship of Dr. Augustine Choi, Weill Cornell Medicine is well-positioned to expand the frontiers of regenerative medicine and pharmaceuticals to the clinic, by establishing the Hartman Institute for Therapeutic Organ Regeneration. This initiative is timely and will lead to discoveries for the treatment of disorders that afflict millions of people worldwide. The recent pandemic was a wake-up call underscoring the revelation that valid scientific evidence and breakthroughs could save humanity and improve the well-being of everyone of different nationalities and ethnic backgrounds.

Thanks to the pioneers at Weill Cornell Medicine (WCM), scientists have already devised patented breakthroughs and innovated game-changing technologies to fully realize the promise of tissue-specific organoids for repairing injured and malfunctioning organs

Galvanizing Blood Vessel Cells to Expand for Organ Transplantation

Scientists have discovered a method to induce human endothelial cells from a small biopsy sample to multiply in the laboratory, producing more than enough cells to replace damaged blood vessels or nourish organs for transplantation, according to a preclinical study by Weill Cornell Medicine investigators.

NIH Funds Study of Type 1 Diabetes Development

Weill Cornell Medicine has received a four-year, $3.4 million grant from the National Institute of Diabetes and Digestive and Kidney Diseases, part of the National Institutes of Health, for a study of the details and dynamics of the autoimmune process that causes type 1 diabetes. Dr.

Small Molecule Treatment Could Make Islet Transplantation Therapy More Effective

A pretreatment step could help transplanted pancreatic islets survive longer in patients with type 1 diabetes, according to a new preclinical study from Weill Cornell Medicine investigators. One combination of small molecules extended the cells’ lives in female mice, and adding two molecules to the mixture boosted cell survival in male mice.

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